G-protein-coupled receptors (GPCRs) are the largest family of membrane proteins and participate in the regulation of most physiological functions being key regulators of signal transduction by which cells respond to variations in their environment. Consequently, GPCRs are the targets of a majority of currently marketed drugs. The recent major discoveries in the knowledge of GPCR function open new perspectives, particularly towards the development of efficient therapies against neurological and psychiatric disorders, genetic diseases and metabolic diseases. The challenge of the IGF GPCR signaling research axis is to integrate structural, pharmacological and cellular insights into GPCR biology to promote the discovery of more efficient, selective and safer drugs.

Coordinator: Bernard MOUILLAC