Team Stéphanie TROUCHE

The appetitive-aversive memory circuit interaction is critical to correctly learn and guide appropriate behaviour. Importantly, such behavioural processes can also be mofidied by the internal state to strengthen memory-guided behaviours. By employing a multi-level approach combining in vivo monitoring of neuronal activity and dopamine kinetics, ex vivo slice physiology and manipulation of activated neuronal ensembles (TetTag technology) using optogenetics and pharmacogenetics in behaving mice, we aim to study 1) the interaction between fear and extinction memories 2) the involvement of reward circuits in aversive learning and 3) how internal state modulates aversive behaviours.

Main publications

• Perisse E, Miranda M and Trouche S. Modulation of aversive value coding in the vertebrate and invertebrate brain. Current Opinion in Neurobiology, 2023 Ap:79:102696.
• Trouche S, Pompili N and Girardeau G. The role of sleep in emotional processing: insights and unknowns from rodent research. Current Opinion in Physiology, 2020 Jun; p230-237.
• Trouche S, Koren V, Doig NM, Ellender TJ, El-Gaby M, Lopes-dos-Santos V, Reeve HM, Perestenko PV, Garas FN, Magill PJ, Sharott A and Dupret D. A hippocampus-accumbens tripartite neuronal motif guides appetitive memory in space. Cell, 2019 Mar 7;176(6):1393-1406.e16.
• Trouche S, Perestenko PV, van de Ven GM, Bratley CB, McNamara CG, Campo-Urriza N, Black SL, Reijmers LG, Dupret D. Recoding a cocaine-place memory engram to a neutral engram in the hippocampus. Nature Neuroscience, 2016 Apr;19(4):564-7.