Team Stéphanie TROUCHE

The ability to distinguish between familiar and novel individuals (social recognition) is key for driving social approach and is evolutionary well conserved. Social recognition is impaired in several neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. Our project aims to study the circuit and synaptic plasticity mechanisms underlying social recognition, using a combination of experimental approaches, including electrophysiology, optogenetic interventions during behaviour and mouse models of neuropsychiatric disorders.

Main publications

• Tuduri P*, Bouquier N*, Girard B*, Moutin E, Thouaye M, Perroy J, Bertaso F, Ster J. Modulation of hippocampal network oscillation by PICK1-dependent cell surface expression of mGlu3 receptors. Journal of Neuroscience, 2022. * contribution égale.
• Berry S, Weinmann O, Fritz AK, Rust R, Wolfer D, Schwab ME, Gerber U, Ster J. Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits. PLoS One, 2018; 3(7):e0200896.
• Rosenberg N, Gerber U and Ster J. Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors. Journal of Neuroscience, 2016; 36(45):11521-11531.