Team Stéphanie TROUCHE
Appetitive and aversive memory circuits
Our lives are built around positive and negative experiences embedded in particular places, contexts and states. These rewarding or punishing experiences can recruit distinct, but also overlapping, neuronal ensembles in different brain circuits, underlying appetitive and aversive memories. The overall goal of our team is to understand how appetitive and aversive neuronal circuits are shaped by past experience, environment (spatial or social) and internal state, and how they interact to select appropriate behaviors such as approach or avoidance.
To reach this goal, we employ in vivo and ex vivo recordings, intersectional viral strategies, pharmacogenetics, close-loop optogenetic intervention, automated behavioural tracking and in situ hybridization in mice. By visualizing, monitoring and manipulating precise neuronal ensembles, the team aims to provide a mechanistic understanding of the cross-talk between the reward and aversive systems. This knowledge will advance our theoretical understanding on psychiatric disorders for which emotional and decision-making processes are altered (e.g., PTSD).
Funding
IGF Nord 113
04 34 35 92 76
IGF Nord 113 04 34 35 92 76
IGF Sud 227 04 34 35 92 10
IGF Sud 113 04 34 35 92 76
IGF Nord 113 04 34 35 92 76
IGF Nord 113 04 34 35 92 76
IGF Nord 113 04 34 35 92 76
IGF Nord 113 04 34 35 92 76- Perisse E, Miranda M and Trouche S. Modulation of aversive value coding in the vertebrate and invertebrate brain. Current Opinion in Neurobiology, 2023 Ap:79:102696.
- Tuduri P*, Bouquier N*, Girard B*, Moutin E, Thouaye M, Perroy J, Bertaso F, Ster J. Modulation of hippocampal network oscillation by PICK1-dependent cell surface expression of mGlu3 receptors. Journal of Neuroscience, 2022. * contribution égale.
- Sasaki Russell J, Trouche S and Reijmers LG. Functional characterization of the basal amygdala – dorsal BNST pathway during contextual fear conditioning. eNeuro, 2020 Jul 13;7(4):.0163-20.2020.
- Trouche S, Pompili N and Girardeau G. The role of sleep in emotional processing: insights and unknowns from rodent research. Current Opinion in Physiology, 2020 Jun; p230-237.
- Trouche S, Koren V, Doig NM, Ellender TJ, El-Gaby M, Lopes-dos-Santos V, Reeve HM, Perestenko PV, Garas FN, Magill PJ, Sharott A and Dupret D. A hippocampus-accumbens tripartite neuronal motif guides appetitive memory in space. Cell, 2019 Mar 7;176(6):1393-1406.e16.
- Berry S, Weinmann O, Fritz AK, Rust R, Wolfer D, Schwab ME, Gerber U, Ster J. Loss of Nogo-A, encoded by the schizophrenia risk gene Rtn4, reduces mGlu3 expression and causes hyperexcitability in hippocampal CA3 circuits. PLoS One, 2018; 3(7):e0200896.
- Rosenberg N, Gerber U and Ster J. Activation of Group II Metabotropic Glutamate Receptors Promotes LTP Induction at Schaffer Collateral-CA1 Pyramidal Cell Synapses by Priming NMDA Receptors. Journal of Neuroscience, 2016; 36(45):11521-11531.
- Trouche S, Perestenko PV, van de Ven GM, Bratley CB, McNamara CG, Campo-Urriza N, Black SL, Reijmers LG, Dupret D. Recoding a cocaine-place memory engram to a neutral engram in the hippocampus. Nature Neuroscience, 2016 Apr;19(4):564-7.
- McNamara CG, Tejero-Cantero A, Trouche S, Campo-Urriza N, Dupret D. Dopaminergic neurons promote hippocampal reactivation and spatial memory persistence. Nature Neuroscience, 2014 Dec 17(12):1658-60.
- Trouche S, Sasaki J, Tu T, Reijmers LG. Fear extinction causes target specific remodeling of basal amygdala perisomatic synapses. Neuron, 2013 Nov20;80(4):1054-65.
Interaction between appetitive and aversive memory circuits
Principal investigator
Stéphanie TROUCHE
2024
• E. Debos (Master 2 Neuroscience, 6 mois).
• C. Sanié, O.Hamidi (Master 1 Neuroscience, 6 mois).
• Tebar (IUT Génie Biologique, 6 semaines).
2023
• C. Bernard (Master 1 MER, 2 mois).
• E. Larche (Master 1 Neurosciences, 6 mois).
• S. Thomas, J.Mameri (L3 APP, 6 semaines)
• E. Baert, M.Bierry, L.Baltimore (L3, 6 demi-journées).
2022
• E. Karam (Master 2 MER, 6 mois),
• L. Izquierdo (L1, 6 semaines).
2021
• P. Fourquin, Vanessa Greggio, Lea Beaujoin (L3, 6 demi-journées).
• L. Vaillant (EPHE Master 2, 6 mois).
2020
• J. Beauduffe (Master 2 Neuroscience, 5 mois).
• J. Grelaud (Master 1 Neuroscience, 6 mois).
• J. Tram (Doctorante-mentee de l’association « Femmes et Sciences », 6 mois).
2019
• E. Abi Habib (doctorante-mentee de l’association « Femmes et Sciences », 6 mois).
• J. Bertin (Master 1 Neuroscience, 4 mois et demi).
• M. Verdy (Master 1 MER, 6 mois).
Public outreach
2024
• Brain week, Mermoz high school, « Cerebral Plasticity», Montpellier, France (3 days, Magdalena Miranda).
2023
• Zoom session Neuromentoring, “How to find a lecturer/researcher position in France?” (Elsa Karam).
• Declic Days, Georges Pompidou high school, Castelnau-le-lez, France (Majda Drahmani).
2022
• Declic Days, Georges Pompidou high school, Castelnau-le-lez, France (Elsa Karam and Stephanie Trouche).
• Declic Days, Georges Pompidou high school, Castelnau-le-lez, France (Majda Drahmani).
• Science festival booth “Super Power of bacteria”, Montpellier, France (Elsa Karam).
Science festival, Village des Sciences, Montpellier (workshop with 40 primary school children, Stéphanie Trouche).
2019
• Conference “Quai des Savoirs”, Toulouse, France.
• Conference at the University of Third Time « Spatial memory and navigation » and «Strategies for searching the memory trace » (Stéphanie Trouche).
2018
• Member of Women and Science association, Montpellier, France. Mentor for PhD students in Science (Stéphanie Trouche).
• Conference at the University of Third Time « Spatial memory and navigation » and «Strategies for searching the memory trace » (Stéphanie Trouche).
• Brain week, Jean Monnet high school, Montpellier, France (2 days, Jeanne Ster).
2017
• Brain week, Jean Monnet high school, Montpellier, France (2 days, Jeanne Ster).
