Team Philippe RONDARD
Neuroreceptors, dynamics and functions
Project Nanobodies targeting mGlu receptors as innovative immunotherapy for the treatment of brain diseases
PRINCIPAL INVESTIGATOR
IGF staff involved
Mireille TSITOKANA
PhD student CNRS
Ugo ALENDA
PhD student UM
Pierre PRIEU-SERANDON
PhD student UM
Pierre-André LAFON
Post-doc CNRS
Jiyong MENG
Post-doc CNRS
Séverine DIEM
IECN CNRS
Célia CAMBERLIN
IE INSERM
There is an urgent need for innovative therapies to treat psychiatric and neurodegenerative diseases. Immunotherapy has proved effective in many medical fields, but there are virtually no antibody-based therapies for brain diseases, mainly due to their poor penetration into the brain. Our recent work has shown that camelid mini-antibodies (nanobodies) hold great promise for the treatment of brain diseases. We have recently established proof of concept that these nanobodies, by targeting the presynaptic mGlu2 receptor, can restore the symptoms of schizophrenia in several preclinical models.
Llama nanobodies as pharmacological and therapeutic tools
Main publications
• Tsitokana ME, et al. (2023) International Journal of Molecular Sciences 24, 2632.
• Scholler P., et al. (2017) Nat Commun 8(1):1967
Funding
• 2024-2026 Equipe FRM – PR Coordinator
• 2023-2026 Prématuration FRM – PR Coordinator
• 2023-2027 ANR NANOTHALZ – PR Coordinator
• 2022-2023 Prématuration FRM – JPPin Coordinator
• 2022-2023 Soutien à la Recherche Univ. Montpellier – PR & JPPin Coordinator
• 2021-2025 ANR NANO4SCHIZO – PR Coordinator
• 2021-2024 ANR SCHIZOGLU – PR Partner
• 2020-2022 Prématuration NANO2VECTEUR Région Occitanie – JPPin Coordinator
• 2020-2021 Maturation initiale NANO4SCHIZO SATT Occitanie AxLR – PR Coordinator
• 2016-2021 ANR NANOGLUACT – PR Coordinator
Collaborations
• Patrick Chames (Marseille)
• Carine Bécamel (Montpellier)
• Denis Servent (CEA Saclay)
• Amy Ramsey & Ali Salahpour (University of Toronto)
• Jean-Pierre Pouget (Montpellier)
• Jean Ster (Montpellier)
• Sylvie Claeysen (Montpellier)
Alumni
• Léo Pion (Ph.D thesis, 2020-2024)
• Roxanne Perrin (Engineer, 2021-2024)
• Jessica Monnic (Engineer, 2021-2023)
• Mathieu Oosterlaken (Ph.D thesis, 2016-2020)
• Pauline Scholler (Ph.D thesis, 2011-2014)
Patents
• Pin J.P., Rondard P., Kniazeff J., Oosterlaken M., Rogliardo A., Becamel C. WO2024003389A1, 2024.
• Pin J.P., Rondard P., Prezeau L., Kniazeff J., Oosterlaken M., Tsitokana M.E., WO2024003390A1, 2024.
• Baty D., Pin J.P., Chames P., Nevoltris D., Rondard P., Scholler P., Mathis G., WO2016/001417, 2016.
