Team Philippe RONDARD
Neuroreceptors, dynamics and functions
Project Complexes of mGlu receptors and their dynamics in native environment
PRINCIPAL INVESTIGATOR
IGF staff involved
Kawthar BELKACEMI
PhD student CNRS
Marine HOSCAR
PhD student UM
Marta CIMADEVILA
Post-doc CNRS
Isabelle BRABET
IEHC CNRS
Our team recently discovered that the eight glutamate receptors (mGlu), considered as homodimers (made up of identical subunits) for a long time, could also form heterodimers, revealing the existence of 16 new mGlu receptors with specific properties. Our aim is to identify the various mGlu heterodimers in the brain, and to develop specific tools to study them (small molecules and nanobodies) and understand their physiological function. These novel glutamate receptors represent new drug targets for neurological and psychiatric diseases.
Metabotropic glutamate receptors form complexes with other GPCRs.
Main publications
• Belkacemi K., et al. (2024) Neuroscience, in press
• Meng J., et al. (2022) Nat Chem Biol, 18, 894-903.
• Moreno-Delgado D., et al. (2017) Elife 6, e25233.
• Liu J., et al. (2017) Elife 6, e26985.
• Doumazane E., et al. (2011) FASEB J, 25, 66-77.
Funding
• 2020-2023 ANR 2020-DOWNALZ – Partner
• 2018-2019 Région Occitanie
• 2022-2026 ANR HeteroGlu7 – Coordinator (JP Pin)
Collaborations
• Francesco Ferraguti (Innsbruck University, Vienna)
Alumni
• Jiyong Meng (Ph.D student, 2015-2022)
• David Moreno-Delgado (postdoc, 2012-2016)
• Pauline Scholler (Ph.D student, 2010-2014)
• Etienne Doumazane (Ph.D student, 2007-2011)
