Team François RASSENDREN

Purinergic signaling and brain inflammation

Project Purinergic signaling and pain

PRINCIPAL INVESTIGATOR

Lauriane Ulmann
MCF, UM

IGF staff involved
Vincent COMPAN
CRCN Inserm
Nathalie LINCK
AI UM
Anne SALVAGE
M2 UM
Lucie GENTIL
M2 UM

Purinergic signaling, and in particular P2X receptors, are involved in the development of inflammatory and neuropathic pain. We are interested in the P2X4 receptor, whose expression is induced in neurons and microglia during periods of high neuronal activity. We aim to determine the mechanisms leading to P2X4 expression, its cellular localization and its role in different cell types and tissues in the context of acute and chronic pain, as well as in associated psychiatric comorbidities.

  1. Visualization of P2X4 receptor (red) in spinal cord microglia (Green)
  2. Microglia in spinal cord in control condition (left) or after neuropathy (right)
Main publications

• Gilabert D et al,(2023), iScience, 26(11):108110.
• Hua et al, (2023), Cell Mol Life Sci, 80(5):138.
• Lalisse et al, (2018), Scientific Reports, 8(1):964.
• Ulmann et al, (2013), Glia, 61(8):1306-19.
• Ulmann et al, (2008), EMBO J, 29(14):2290-300.

Funding

• 2020-2024 ANR 2020-PURPLEPAIN – Porteuse
• 2018-2020 : Fondation NRJ
• 2015 : Institut UPSA
• 2013 : Chercheur d’avenir région Languedoc Roussillon

Collaborations

• Eric Boué-Grabot (Bordeaux)
• Thomas Grutter (Strasbourg)
• Pascal Fossat (Bordeaux)
• Vincent Compan (Montpellier)

Alumni

• Jennifer Hua (Thesis)
• Sarah Lalisse (Thesis)
• Valentine Charmes (Master)
• Eloise Pascal (Master)
• Manon Lenoir (Master)
• Amandine Falco (Master)