Team François RASSENDREN

Purinergic signaling and brain inflammation

François Rassendren
DR1, CNRS

The team is interested in the signaling mechanisms involved in neuroinflammatory manifestations with a particular interest in purinergic signaling. In the nervous system glial cells, microglia and astrocytes, are the main immunocompetent cell types. In the event of a breakdown in homeostasis, these cells move from homeostatic to reactive states, characterized by functional remodeling and the acquisition of inflammatory properties. We are interested in these functional remodelings in different acute and chronic pathologies in terms of signaling and transcriptional modifications with the aim of identifying new potential therapeutic strategies.