Team Julie PERROY

Signaling involved in post-synaptic plasticity comprises various pathways, including early messengers such as calcium ion and cyclic AMP, usually converging towards integrator kinases like ERK. These pathways interact in a dynamical fashion, at temporal scales ranging from millisecond to minutes. Data from living animals are very parse, such that signaling dynamics during behavior are still unknown. We aim at recording simultaneously several signaling activities in neuronal ensembles during learning. To this end, we developed a confocal fiberscope allowing fluorescence and BRET imaging of original biosensors, and record from hippocampal place cells during spatial navigation.