Team Patrice MOLLARD
Networks and rhythms in endocrine glands
Project Circadian clock versatility in health and disease
PRINCIPAL INVESTIGATOR
IGF staff involved
Laura CASTEL
AI INSERM
François MOLINO
MCU UM
Chrystel LAFONT
IR INSERM
Evelyne GALIBERT
T CNRS
Patrice MOLLARD
DR CNRS
Our circadian clock synchronizes our body with the day-night cycle (hormonal rhythms, sleep-wake cycle…). Paradoxically, while this biological clock confers an adaptive advantage in our natural environment, its robustness is sometimes an obstacle in our modern society, active day and night (depression, diabetes and cancer associated with night work; jetlag…).
Faced with this yin-yang of the clock, we address mechanisms accounting for physiological or pathological circadian versatility, which would then enable to better adjust our internal rhythms to our social constraints.
We study circadian rhythms at the molecular, cellular and behavioral levels, and their modularity during various physiological and pathological situations, such as lactation or hypothyroidism. In vivo imaging of cellular calcium using microendoscopy is a cutting-edge technique for longitudinally monitoring the functional plasticity of the neuronal network in the suprachiasmatic nuclei (SCN), where the circadian pacemaker resides.
Further information:
Emission France Bleu – A Montpellier, on étudie la régulation de l’horloge interne…sur des souris
FRC – Troubles de l’humeur et maladies thyroïdiennes : une perturbation du tic-tac de l’horloge interne ?
In vivo monitoring of daily variations in cellular calcium concentration in the SCN. The fluorescence emitted by the calcium probe GCamp6f is collected through a GRIN lens every 2 hours for 24 hours at a cellular resolution, in a freely moving mouse.
Main publications
• Guillou A, et al. (2023) Endocrinology, 165(1), bqad164.
• Davidson AJ, et al. (2023) Biology (Basel), 12(8), 1136.
• El Cheikh Hussein L, et al. (2022) PNAS Nexus, 1(3), pgac112.
• Vila IK, et al. (2022) Cell Metab, 34(1), 125-139.
• El Cheikh Hussein L, et al. (2019) Int J Mol Sci, 20(8), 2052.
• Abitbol K, et al. (2017) PLoS One, 12(10), e0187001.
Funding
• 2022-2023 Fondation pour la Recherche sur le Cerveau – Coordinator
Collaborations
• Federica Bertaso & Emmanuel Valjent (Montpellier)
• Frédéric Castinetti (Marseille)
• Arnaud Monteil (Montpellier)
• Kazuhiro Yagita (Kyoto)
• Frédéric Flamant (Lyon)
Alumni
• Lama El Cheikh Hussein (Thèse)
• Morgane Chemarin (M2)
• Rachel Bourdon Alonzeau (M2)
• Karine Abitbol (Post-doc)
