Team Philippe MARIN
Neuroproteomics and signalling of brain disorders
Projects Normal and pathological functions of Tau / Eco-emotions and mental health
PRINCIPAL INVESTIGATOR
IGF staff involved
Julien VILLENEUVE
CRCN – CNRS
Sylvie CLAEYSEN
CRHC – Inserm
Philippe MARIN
DRCE CNRS
Aurore FILAQUIER
PhD student UM
Eloïse NEEL
PhD student CNRS
Morgane DENUS
IE CNRS
Eco-emotions project
Sylvaine ARTERO
CRCN Inserm
Julien VILLENEUVE
CRCN – CNRS
Emilie OLIE
PU-PH2 UM
I’m working on two topical societal issues. The first, following on from my previous work, is to understand the normal and pathological functions of the Tau protein, a key factor in the progression of several neurodegenerative diseases, including Alzheimer’s disease. The prevalence of these diseases will continue to rise in France as the population ages. Discovering new Tau functions based on knowledge of its direct and functional interactors will enable us to better develop therapeutic strategies targeting this factor.
The second area of my work relates to the perception of the current environmental crisis, particularly by the younger generations, in connection with the emergence of eco-emotions such as eco-anxiety, eco-angry or eco-sadness. The characterisation and understanding of these ‘new’ emotions and their impact, particularly on mental health, is a major challenge facing society today. It is in response to this challenge that I have initiated this new research theme within the IGF.
Normal and pathological functions of Tau
Our project involves studying and understanding the normal and pathological functions of Tau, a protein implicated in numerous neurodegenerative diseases such as Alzheimer’s disease. Among the cellular processes studied, we are particularly interested in cell division, neuronal differentiation or increased unconventional secretion under conditions of Tau excess. Among the biochemical processes, we are studying in particular the different patterns of Tau phosphorylation, in relation to its cleavage under conditions of cellular stress, in particular in the presence of an excess of A peptide, in order to understand the key stages in the pathophysiological evolution of Alzheimer’s disease.
To achieve this, we consider Tau interactors, known from two different strategies: 1) proteomic analyses of interactors that immunoprecipitate with Tau under physiological or pathological conditions, 2) a genetic screen to isolate functional interactors from excess Tau.
The techniques we use range from cell biology, including high-resolution microscopy, to the use of model organisms such as Drosophila or Zebrafish, and the analysis of cerebrospinal fluid from patients with different tauopathies.
This research project will enable us to understand the impact of excess tau in the developing nervous system, as well as in adults. In addition to increasing knowledge, it will also have an impact on the definition of new therapeutic and diagnostic strategies in the field of tauopathies.
Main publications
• Filaquier A., et al. (2022) Curr Opin Cell Biol, 16;75:102072.
• Bougé A.L. and Parmentier M.-L. (2016) Dis Model Mech, 10.1242/dmm.022558
• Lepicard S., et al. (2014) J Neurosci, 14:6759-71, 10.1523/JNEUROSCI.4282-13.2014
• Talmat-Amar Y., et al. (2011) Hum Mol Genet, 20:3738-45, 10.1093/hmg/ddr290
• Franco B., et al. (2004) J Neurosci, 24 : 6573-7, 10.1523/JNEUROSCI.1580-04.2004
• Bellaïche Y., et al. (2001) Cell,106 : 355-66, 10.1016/s0092-8674(01)00444-5
• Parmentier M.-L, et al. (2000) J Neurosci, 20 : RC84, 10.1523/JNEUROSCI.20-14-j0003.2000
Funding
• 2024-2026 CoEN- Coordinator
• 2024-2026 Université de Montpellier – Coordinator
Collaborations
• Yoan Arribat (IRMB, Montpellier)
• Ana Boulanger (IGH, Montpellier)
• Carole Crozet (INM, Montpellier)
• Sylvain Lehmann (CHU, Montpellier)
• Mireille Rossel (MMDN, Montpellier)
• Tristan Bouschet (IGF, Montpellier)
Alumni
• William Fargues (Master & Engineer, 2023-2024)
• Adrià Martinez (Master, 2023)
• Amélie Vidal (Master, 2023)
• Lola ARGENSON (Master, 2022)
• Ariane BROWER (Master, 2022)
• Elisa GARBAYE (Master, 2022)
• Thomas Curel (Master 2021)
• Solène Roudet (Master, 2021)
• Candie Chab (Master, 2021)
• Kelly Zarka (IUT, 2018)
• Marion Goussard (Master, 2017)
• Caroline Sauvage (Master, 2017)
• Caroline Noé (Master, 2015)
• Anna Popkova (Post-doc, 2013-2014)
• Simon Lepicard (Doctorat, 2013)
• Yasmina Talmat-Amar (Doctorat, 2012)
• Yoan Arribat (Doctorat, 2012)
• Anne-Laure Bougé (Post-doc, 2010-2013)
• Marjorie Laurans (Master, 2009)
• Christelle Clouet-Redt (Post-doc, 2007-2008)
• Bénédicte Franco (Doctorat, 2007)
• Laurent Bogdanik (Doctorat, 2005)
Eco-emotions and mental health
The aim of this project is to answer a number of questions relating to eco-emotions: How do they differ from the usual emotions experienced in the face of life’s ups and downs, and why do some people experience them more than others? How do they contribute to a commitment to environmental action? How do they impact on people’s mental health? Our work in this area involves qualitative and quantitative surveys, using various measurement scales that have been characterised or are in the process of being characterised. We have highlighted the value of measuring eco-anxious reactions as a whole, i.e. by combining the measurement of the level of eco-anxiety and the measurement of symptoms associated with severe eco-anxiety.
These surveys are directly linked to current public issues, and are also designed to be as participatory as possible. If you would like to take part in this research or find out more about any of them, please contact us.
Main publications
• Parmentier M.-L, et al. (2024) J. Anx. Dis., 101, 102799, 10.1016/j.janxdis.2023.102799.00
Funding
• 2024-2026 University of Montpellier – coordinator
• 2024-2025 University of Montpellier
Collaborations
• Oscar Navarro (Université de Nîmes)
• Karine Weiss (Université de Nîmes)
• Christian Reynaud (Université de Montpellier)
• Lucille Soulier (Université de Montpellier)
• Sergine Ponsard (Université Toulouse Paul Sabatier)
• Christophe Andalo (Université Toulouse Paul Sabatier)
• Sophie Agulhon (Université Paris 8)
• Équipe du projet Respires (CIRAD, Inrae, IRD, CEFE, MSH-Sud, https://www.projet-respires.org/)
• Management Committee Member of COST action CliMent (Climate Change Impact on Mental Health in Europe), 2024-2028
• Clara Sallé (Master 2, University of Nîmes, 2024) codirection with Elsa Causse
• Aya Aroua, Camille Betry, Mathilda Rivière (Master 1 Collaborators, University of Nîmes, 2022)
