Team Philippe LORY
Ion channels in neuronal excitability and diseases
Project Therapeutics of muscle weakness related to the sodium channel Nav1.4
PRINCIPAL INVESTIGATOR
IGF staff involved
Philippe LORY
DR1 CNRS
Nathalie GUERINEAU
DR1 CNRS
Claire BERNAT
IECN CNRS
Angel MAUNIER-MERCIER
AI Inserm
The sodium channel Nav1.4 is expressed in the membrane of muscle cells. It is required to generate the signal for muscle contraction. We have demonstrated that reduced function of Nav1.4 leads to myopathic (CMYP22) or myasthenic (CMS16) syndromes. There are no specific drugs to improve muscle function in these diseases. We work to identify compounds that could do this by screening libraries of natural or synthetic compounds using high throughput screening in cells and testing their efficacy on muscle force in relevant physiological models.
Main publications
• Nicole S. & Lory P. (2021) Front Pharmacol. 12,751095.
• Kokunai Y. et al (2018) Sci Rep, 8, 16681.
• Poulin H. et al (2018) Sci Rep, 8, 2041.
• Nicole S. et al (2017) J Neuromuscul Dis.4,269.
• Kato H. et al (2016. J Neurol Sci, 369,254.
• Habbout K. et al (2016) Neurology, 86,161.
• Loussouarn G. et al (2016) Front Pharmacol, 6,314.
Funding
• 2023-2024 AFM Telethon (coordinator)
• 2022-2023 Fondation Maladies Rares (coordinator)
• 2018-2020 AFM Telethon (coordinator)
Collaborations
• Angelo Torrente (Montpellier)
• Michel de Waard (Nantes)
• Smartox Biotechnoloy (Grenoble)
• Kantify (Bruxelles)
