Team Philippe LORY

The NALCN ion channel is a key player of cell excitability, especially in neurons and endocrine cells. Mutations in the NALCN gene are described to be responsible of genetic diseases in humans. There are no therapeutics identified to date for patients. In this context, research programs carried out in the laboratory aim to understand the physiological roles of NALCN to better understand why its dysfunction induce a pathological state. It is expected to ultimately be able to propose therapeutics to patients. This project is based on the study of original models and tools we developed along with a more than 25-year-old expertise recognized worldwide.

Main publications

• Monteil, A. et al. (2024) Physiol Rev 104, 399-472.
• Folcher, A. et al. (2023) EMBO J 42, e112198.
• Milman, A. et al. (2021) J Physiol 599, 1855-1883.
• Impheng, H. et al. (2021) FASEB J 35, e21400.
• Guerineau, N.C. et al. (2021) Front Neuroendocrinol 63, 100947.
• Bouasse, M. et al. (2019) Sci Rep 9, 11791.
• Chong, J. X. et al. (2015) Am J Hum Genet 96, 462-473.
• Cochet-Bissuel et al. (2014) Front Cell Neurosci 8, 132.
• Boone, A.N. et al. (2014) PLoS One 9, e98808.
• Senatore, A. et al. (2013 PLoS One 8, e55088.
• Swayne, L A. et al. (2010) Islets 2, 54-56.
• Swayne, L. A. et al. (2009) EMBO Rep 10, 873-880.
• Snutch, T. P. & Monteil, A. (2007) Neuron 54, 505-507.

Funding

• 2024 Fondation Maladies Rares
• 2022-2025 ERA-NET NEURON
• 2022 Programme d’échange Blatand (Danemark)
• 2021-2022 Appel d’offre interne IGF avec Xavier Bonnefont
• 2020 Appel à projet PHENOMIN
• 2020-2021 Programme d’échange Hubert Curien Siam (Thaïlande)
• 2018 Programme de recherche conjoint CNRS-Université de Toronto
• 2017-2020 Fondation pour la Recherche Médicale (Partner)
• 2016 Association Française contre les Myopathies
• 2014 Fondation Maladies Rares
• 2013-2014 Programme d’échange Hubert Curien Siam (Thaïlande)
• 2012-2014 Agence Nationale de la Recherche
• 2010 Conseil scientifique de l’Université de Montpellier
• 2010-2012 Laboratoires Servier
• 2007-2008 Programme National de Recherche sur le Diabète de l’INSERM et de l’Association de Recherche sur le Diabète

Collaborations

• Emmanuel Valjent (IGF, France)
• Xavier Bonnefont (IGF, France)
• Hélène Hirbec (IGF, France)
• Natalia Prevarskaia (Université de Lille, France)
• Nawale Hadouiri & Christel Thauvin (CHU de Dijon, France)
• Stephan Pless (University of Copenhagen, Danemark)
• Isabel Del Pino Pariente (Universitat de Alicante, Espagne)
• Antonio Gil-Nagel Rein (Hopital International Ruber, Espagne)
• Leszek Lisowski (University of Sidney, Australie)
• Adriano Senatore (University of Toronto, Canada)
• Jeremy Tanner (University of Texas, Etats Unis)
• Narawut Pakaprot (Mahidol University, Thaïlande)
• David Spafford (University of Waterloo, Canada)
• Michael Bamshad (University of Washington, Etats Unis)

Alumni

• Lidiane Pereira Garcia (Postdoctoral fellow, 2022-2023)
• Sujira Chedsadavitayakul (Master 2 student, 2023)
• Marion Chevallier (Master 1 Student, 2022-2023)
• Romain Baudat (Master 2 student, 2022)
• Julien Grelaud (Master 2 student, 2021)
• Auemphon Mordmuang (Postdoctoral fellow, 2019)
• Tipsuda Thongbuakaew (Postdoctoral fellow, 2018)
• Zoé Servant (CDD AI CNRS, 2018-2020)
• Hathaichanok Impheng (PhD student, 2016-2020)
• Andie Godo (CDD AI CNRS, 2016-2017)
• Phanit Koomhin (Postdoctoral fellow, 2015)
• Marie Sangamayya (Master 1 student, 2015)
• Malik Bouasse (PhD student, 2014-2017)
• Maud Cochet (Post-Doctoral fellow, 2012-2015)
• Samer Khoury Hanna (CDD AI CNRS, 2010-2011)
• Silviya Hristova (Master 1 student, 2007)
• Leigh Anne Swayne (Postdoctoral fellow, 2006-2008)
• Aurélie Le Feuvre (Master 2 student, 2003-2004)