Team Guillaume LEBON – Cyril GOUDET
Molecular and Structural Mechanisms of Neuromodulation
Project Therapeutic innovation and photopharmacology
PRINCIPAL INVESTIGATORS
IGF staff involved
Fanny MALHAIRE
IE CNRS
Iona TRUONG
PhD Student Inserm
Laura TOURNOIS
PhD Student UM
To better study and understand the neurobiological function of G protein-coupled receptors, it is crucial to have an intimate knowledge of their activation mechanisms at molecular and cellular level, and to have pharmacological tools capable of precisely targeting these receptors in their native environments.
Photopharmacology
Photopharmacology is an emerging strategy that enables biomolecules to be controlled with great spatial and temporal precision by light, through the use of photocontrollable ligands. In collaboration with medicinal chemistry and photochemistry teams, a large part of our work is devoted to developing photopharmacological toolboxes for GPCRs, and more specifically receptors activated by the neuromediators glutamate or adenosine.
Principle of cell-based photopharmacology
Main publications
• Dumazer A., et al. (2024) ACS Chem Neurosci 15, 645-655
• Berizzi, A. E. & Goudet, C. (2020) Adv Pharmacol 88, 143-172
• Ricart-Ortega, M.*, Berizzi, A.*, et al. (2020) ACS Pharmacol Transl Sci 3, 883-895
• Goudet, C. et al. (2018) Cur Op Pharmacol 38, 8-15
• Gomez-Santacana, X. et al. (2017) ACS Cent Sci 3, 81-91
• Rovira, X. et al. (2016) Cell Chem Biol 23, 929-934
• Pittolo, S. et al. (2014) Nat Chem Biol 10, 813-815
Funding
• 2020-2024 MUSE Univ Montpellier GAIA – Partner
• 2018-2023 Neuron eranet MAGNOLIA – Coordinator
• 2018-2020 PICS CNRS NEUROPHOTOPHARMACOLOGY – Coordinator
• 2017-2020 ANR2016 EXPLORER – Coordinator
• 2013-2016 Neuron eranet LIGHTPAIN – Partner
Collaborations
• Amadeu Llebaria (Barcelone)
• Rob Leurs (Amsterdam)
• Olalla Vazquez (Marbourg)
Alumni
• Anaelle Dumazer (Thèse cotutelle Univ Montpellier – Univ Barcelona)
• Maria Ricart-Ortega (Thèse cotutelle Univ Barcelona – Univ Montpellier)
• Alice Berizzi (postdoc)
• Xavier Rovira (postdoc)
Patents
• Llebaria, A.; Gorostiza, P.; Gomez Santacana, X.; Pittolo, S.; Giraldo, J.; Rovira, X.; Goudet, C.; Pin, J. P. Glutamate receptors photomodulators. WO2015044358, 2015
Discovery of new compounds of therapeutic interest
GPCRs represent major targets for the discovery and design of new molecules of therapeutic interest. Structural analysis of the GPCRs developed in the team gives access to their activation mechanism and also to the ligand binding mode at the atomic scale. We use this structural information to design molecules that modulate receptor activity.
Structure and pharmacology of mGluRs
Main publications
• Kampen S. et al. ACS Chem Biol. 2022 Oct 21;17(10):2744-2752
• Perryman R. et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2116289119
Collaborations
• Jens Carlsson, Uppsala University, (Stockholm, Sweden)
• Xiajing Cong, IGF (Montpellier, France)
• Lionel Larue, Institut Curie (Paris, France)
