Team Guillaume LEBON – Cyril GOUDET

GPCRs are receptors composed of a conserved seven-helix transmembrane domain (7TM). GPCRs are subject to important structural dynamics that underlie their biological functions and signal transduction. It is important to understand the conformational changes in the receptor associated with its biological functions. We are using crystallography, X-ray diffraction and electron microscopy under cryogenic conditions to characterise the sequence of events induced by the binding of ligands such as the neurotransmitter glutamate or the neuromodulator adenosine, which ultimately lead to signal transduction and the activation of intracellular signalling partners.

Main publications

• Cannone G#, Berto L# et al. BioRxiv 2023, doi: 10.1101/2023.11.07.565819
• Nasrallah C et al. Cell Rep. 2021 Aug 31;36(9):109648.
• Nasrallah C et al. Sci Rep. 2018 Mar 13;8(1):4407.
• Venkatakrishnan AJ et al. Nature. 2016 Aug 25; 536(7617):484-7
• Magnani F et al. Nat Protoc. 2016 Aug;11(8):1554-71
• Lebon G et al. Mol Pharmacol. 2015 Jun;87(6):907-15
• Lebon G et al. Nature. 2011 May 18;474(7352):521-5

Funding

• 2024-2025 Muse, Université de Montpellier (Contrat de recherche exploratoire)
• 2023-2024 Ligue Occitanie – Porteur
• 2021-2024 ANR SWITCH-ON – Porteur
• 2019-2024 Ligue contre le cancer (PhD Fellowship)
• 2016-2017 Université de Montpellier (Post-doc)
• 2013-2018 ATIP-Avenir
• 2013-2015 FRM (IR)

Collaborations

• Dr Giuseppe Cannone; MRC-LMB (Cambridge, UK)
• Dr Vinothkumar Kutti Ragunath; NCBS (Bangalore, India)
• Dr Jacques Philipp Colletier; IBS (Grenoble, France)

Alumni

• Dr. Nasrallah Chady (Post-doctorant, 2014-2018)
• Dr. Julie Briot (Post-doctorante, 2014-2018)
• Dr. Ludovic Berto (Doctorant, 2019-2023)
• Dr. Gavin Fergusson (Post-doctorant, 2021-2023)
• Dr. Bettina Frank (Post-doctorante, 2021-2023)