Team Freddy JEANNETEAU

Stress hormones & plasticity

Freddy Jeanneteau
DR2, CNRS

ATIP-AVENIR team created in 2013, consolidated into Team-FRM in 2018 affiliated with the national network on autism and neurodevelopmental disorders, the network on neurodegenerative diseases, the Occitanie perinatal network and the international neurobiology of stress network.
Type of research: preclinical and translational
Our discoveries are qualified as scientific highlights by peer societies in 2016, 2018, 2019, 2021 and 2023.

We seek to identify mechanisms of brain plasticity to be diverted to correct neurological and psychiatric pathological trajectories. We apply this strategy on animal models and when possible, we involve clinicians to accelerate the transition to humans. For 10 years, our research has focused on the protective properties of neuropeptides (Oxytocin, Vasopressin, Somatostatin, BDNF, PDGF-BB) on the brain pushed to the limits of its plasticity in supra-physiological and pseudo-pathological conditions.
Today our research is focused on the fields of neuroprotection applied to the maintenance and construction of neural connectivity networks from birth to aging.

The funders are the ANR, the NIH, the foundation for medical research, FP7, Horizon Europe, France Alzheimer…

© Parvathi Nair / © MattLphotography/Alamy

PROJECTS IN PROGRESS

Metabolomics and epigenomics of depression and treatment resistance

Oxytocin and vasopressin: Effective treatments for autism?

Cognition and nutrition

Treatment of observational post-traumatic stress syndrome

Team leader
Freddy
Jeanneteau
DR2, CNRS
  IGF Nord 020a
  04 34 35 92 95
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Researchers
Pascal
Colson
PH, CHU
  CHU
  04 67 33 59 57
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Postdoctoral researchers and doctoral students
Thamyris
Santos Silva
Chercheur CDD, Inserm
  IGF Nord 019c1
  04 34 35 92 93
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Trainees
Tamara
Nikolic
Stagiaire, CNRS
  IGF Nord 020a
  04 34 35 92 95
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  • Dromard Y, Borie AM, Chakraborty, Guillon G, Muscatelli F, Desarménien M, Jeanneteau F.Disengagement of somatostatin neurons from lateral septum circuitry by oxytocin and vasopressin restores social-fear extinction and suppresses aggression outbursts in Prader-Willi syndrome model. Biological Psychiatry. 2023 Oct 27 (In press) doi : 1016/j.biopsych.2023.10.016
  • Jeanneteau F. Stress and the risk of Alzheimer dementia: Can deconstructed engrams be rebuilt? J Neuroendocrinol. 2023 Jan 25:e13235. doi: 10.1111/jne.13235
  • Dromard Y, Arango-Lievano M, Borie A, Dedin M, Fontanaud P, Torrent J, Garabedian MJ, Ginsberg SD, Jeanneteau F. Loss of glucocorticoid receptor phosphorylation contributes to cognitive and neurocentric damages of the amyloid-β pathway. Acta Neuropathol Commun. 2022 Jun 22;10(1):91. doi: 10.1186/s40478-022-01396-7
  • Borie AM, Dromard Y, Guillon G, Olma A, Manning M, Muscatelli F, Desarménien MG, Jeanneteau F. Correction of vasopressin deficit in the lateral septum ameliorates social deficits of mouse autism model. J Clin Invest. 2021 Jan 19;131(2):e144450. doi: 10.1172/JCI144450.
  • Dromard Y, Arango-Lievano M, Fontanaud P, Tricaud N, Jeanneteau F. Dual imaging of dendritic spines and mitochondria in vivo reveals hotspots of plasticity and adaptation to stress. Neurobiology of Stress. 2021;15:100402. doi:10.1016/j.ynstr.2021.100402
  • Jeanneteau F, Arango-Lievano M, Chao Neurotrophins and synaptogenesis. In Comprehensive Developmental Neuroscience: Synapse development and maturation. 2019. Editor-in-Chief J Rubenstein & P. Rakic (1st Edition). Elsevier. 167-184
  • Arango-Lievano M, Borie AM, Dromard Y, Murat M, Desarmenien MG, Garabedian MJ, Jeanneteau F. Persistence of learning-induced synapses depends on neurotrophic priming of glucocorticoid receptors. Proc Natl Acad Sci USA. 2019 Jun 25;116(26):13097-13106 doi: 10.1073/pnas.1903203116
  • Arango-Lievano M, Boussadia B, De Terdonck LDT, Gault C, Fontanaud P, Lafont C, Mollard P, Marchi N, Jeanneteau Topographic Reorganization of Cerebrovascular Mural Cells under Seizure Conditions. Cell Rep. 2018 Apr 24;23(4):1045-1059 doi: 10.1016/j.celrep.2018.03.110
  • Arango-Lievano M, Lambert WM, Bath KG, Garabedian MJ, Chao MV, Jeanneteau Neurotrophic-priming of glucocorticoid receptor signaling is essential for neuronal plasticity to stress and antidepressant treatment. Proc Natl Acad Sci USA. 2015 Dec 22;112(51):15737-42 doi: 10.1073/pnas.1509045112
  • Liston C, Cichon JM, Jeanneteau F, Jia Z, Chao MV, Gan WB. Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nature Neurosci. 2013 Jun;16(6):698-705 doi: 10.1038/nn.3387

• Highlights of the société de Neuroendocrinologie 2023: publi Team
• Highlights of the société des Neurosciences 2023: publi Team
• Highlights of the société de Neuroendocrinologie 2021: publi Team
• Young researcher prize from the neuroendocrinology society 2021: Amélie Borie
• Highlights of the société de Neuroendocrinologie 2019: publi Team
• Highlights of the société des Neurosciences 2019: publi Team
• Cover of Journal of Neuroscience 2018: Publi Equipe
• Highlights of the société de Neuroendocrinologie 2018: publi Team
• Major scientific advances from the Rabelais pole 2016: Margarita Arango-Lievano
• Cover of Neurobiology of disease 2016: Publi Equipe
• AD/PD Young Researcher Prize 2016: Margarita Arango-Lievano
• Coverage of PNAS 2015: Publi Equipe
• Jean Valade Medical Prize 2014: Freddy Jeanneteau

• Gilles Guillon (research director 2013-2022)
• Michel Desarmenien (research director 2013-2021)
• Maithe Corbani (Researcher 2013-2019)
• Hasan “Hugo” Lamat (MD PhD student 2021-2022)
• Masha Meger (undergraduate student 2022)
• Audrey Mignon (graduate student 2021)
• Maria-Jose Queipo Garcia (Visiting PhD student 2019)
• Berenice Pommier (graduate student 2020-2021)
• Nora Mekki (graduate student 2019-2020)
• Julie Bessie (undergraduate student 2020)
• Myriam Atouf-Gazi (graduate Student 2020)
• Nadia Djaa (Pharmacy student 2020)
• Geoffrey Stuart-Lopez (Engineer 2017-2019)
• Tom Malaval (undergraduate student 2021)
• Said Bihairi (undergraduate student 2021)
• Damien Huzard (postdoc 2019-2021)
• Amelie Borie (Phd student 2014-2020)
• Fanny Andreu (Pharmacy student 2020)
• Laurie Maubernard (undergraduate student 2020)
• Margarita Arango-Lievano (Postdoc 2013-2018)
• Emi Pollozi (Undergraduate student 2020-2021)
• Rafik Marir (Visiting assistant professor 2019)
• Maria Moreno (graduate student 2018-2019)
• Maxime Murat (undergraduate student 2018)
• Lydia Boumensour (Visiting assistant professor 2018)
• Djodi Dufner (Pharmacy student 2019)
• Camille Peguet (undergraduate student 2019)
• Marine Bernadet (Undergraduate student 2018)
• Lucile Du Trieu de Terdonck (Graduate student 2017-2018)
• Camille Gault (undergraduate student 2017)
• Oriane Lannes (undergraduate student 2017)
• Amir Hachaichi (undergraduate student 2017)
• Maxime Manière (PhD Student 2013-2016)
• Ilies Hamrass (undergraduate student 2016)
• Lydia Boumensour (Visiting PhD student 2016)
• Matthias Catteau (Graduate student 2016-2017)
• Maxime Murat (Undergraduate student 2016)
• Geraldine Petit (postdoc 2016-2017)
• Elisabete Augusto (Postdoc 2016-2017)
• Margaux Capeera (Undergraduate student 2017-2018)
• Benjamin Combes (undergraduate student 2016)
• Vera Boulay (Technician INSERM 2013-2015)
• Cedric Bertrand (graduate student 2015)
• Meidiha Ouzal (undergraduate student 2015)
• Emilie Maruhenda (Graduate Student 2014-2015)
• Julie Mion (PhD student 2013-2014)
• Magda Chafai (Visiting graduate student 2013)
• What causes social fears?
Featured by Institut national des sciences biologiques – Read the article

• Neurobiology of tantrums
Featured by Happiest Health – Read the article

• Vasopressin to treat autism spectrum disorders
Featured by Spectrum – Read the article

• Dissociating the beneficial and harmful effects of glucocorticoids to fight Alzheimer’s disease’s
Featured by Institut national des sciences biologiques – Read the article

• Plasticity of engram synapses necessary for antidepressant efficacy
Read the article

• Fitness of synaptic mitochondria is programmable
Featured by Institut national des sciences biologiques – Read the article

• PDGF-BB to regenerate the neurogliavascular unit in neurological disorders
Read the article

• Gene therapy with DUSP1 minigene, a new TAU kinases phosphatase
AD/PD selected hot topic 2016 – Read the article

• Synaptic bases of glucocorticoid mnemonic effects
Read the article

• Lipidation of a protein receptor causes biased signaling
Read the article