Team Sébastien GRANIER – Bernard MOUILLAC

G protein-coupled receptors (GPCRs) are membrane proteins that regulate most of human physiological function with more than 800 different members. They are established drug targets in the treatment of diseases of major systems, including the central nervous system, cardiovascular, respiratory, metabolic and immune systems. The GPCR field has recently witnessed a structural revolution with the development of experimental and in silico-based methods opening the way for the design of innovative and safe drugs. To participate to this effort, we are deciphering the molecular and structural mechanisms of key concepts in GPCRs function including: allosteric and orthosteric ligand binding, protein-protein interaction, biased signaling and dynamic of activation.

Main publications

• Bous J, Fouillen A et al. (2022) Science Adv. Sep 2;8(35)
• Droctové L et al (2022) British Journal of Pharmacology Jul;179(13):3470-3481.
• Cong, X et al. (2021) Mol Cell. Oct 21;81(20)
• Bous J, et al. (2021) Sci Adv. May 21;7(21)
• Droctové L et al. (2020) Theranostics, Sep 18;10(25):11580-11594.
• Perkovska S et al. (2018) Traffic Jan;19(1):58-82.
• Ciolek J et al. (2017) Proc. Nat. Acad. Sci. USA Jul 3;114(27):7154-7159.
• Sounier R, et al. (2015) Nature. Aug 20;524(7565):375-8.
• Jean-Alphonse F et al. 2009 J Am Soc Nephrol. Oct;20(10):2190-203.

Funding

• 2023-2027 ANR 2023-V2Cure – Coordonnateur
• 2022-2025 Equipe FRM
• 2021-2026 ANR 2021-Polyfado – Partenaire
• 2019-2023 ANR 2019-StrainV2 – Coordonnateur
• 2019-2024 ANR 2019-OCHRE – Partenaire
• 2019-2024 ONCORNET2 2019 – Partenaire

Collaborations

• Gunnar, Schulte (Stockholm)
• Nicolas, Gilles (CEA, Saclay)

Alumni

• Chorfa Amélia (Thèse 2018-2022)
• Bous Julien (Thèse, 2017-2021)

Patents

• Gilles G, Servent D, Quinton L, Reinfranck H, Witzgall R, Mouillac B, Mendre C. 2015 Brevet international n° EP2895189-2015-07-22.