Team Sébastien GRANIER – Bernard MOUILLAC
Membrane Protein Structure and Function for Drug Discovery (MAGIC)
Project G protein-coupled receptors and pathogens
PRINCIPAL INVESTIGATOR
IGF staff involved
Cédric LEYRAT
CRCN INSERM
Rémy SOUNIER
CRCN INSERM
Aurélien FOUILLEN
Postdoc CNRS
Elodie LOGEROT
Postdoc INSERM
Tristan GIRBAU
IE INSERM
Zainab AMMAR
IE INSERM
Many deadly pathogens are exploiting the presence of G protein-coupled receptors (GPCRs) at the surface of human cells through the binding and the control of their function to ultimately invade and kill organisms. Blocking this hijacking process by preventing pathogens to bind and control GPCR signaling constitutes an attractive but underexplored strategy. In our laboratory, we are particularly interested in determining the molecular, structural and pharmacological mechanism allowing pathogens, by using specific secreted proteins, to target host GPCRs.
Main publications
• Lambey P, et al. (2022) Elife Mar 21;11:e72555
• Grison CM, et al. (2021) Proc Natl Acad Sci U S A. Oct 19;118(42)
Funding
• 2021-2025 ANR 2021-LEUKOCEPTOR – Coordonnateur
Collaborations
• Françoise Bachelerie (Paris)
• Emmanuel Margeat/Robert Quast (Montpellier)
Alumni
• Camille Le Drezen (IE, INSERM)
• Elise Del Nero (IE, INSERM)
• Sylvain Jeannot (IE, INSERM)
• Claire Grison (Post-doc, UM)
• Paul Lambey (IE, INSERM)
