Team Sébastien GRANIER – Bernard MOUILLAC
Membrane Protein Structure and Function for Drug Discovery (MAGIC)
Project Ceramide Homeostasis
PRINCIPAL INVESTIGATOR
IGF staff involved
Rémy SOUNIER
CRCN INSERM
Chérine BECHARA
Professor UM
Cédric LEYRAT
CRCN INSERM
Pierre COUVINEAU
Postdoc INSERM
Rym BEN BOUBAKER
Postdoc CNRS
Juliette DIMON
IE INSERM
Ceramides are biomolecules at the core of sphingolipid biology regulating critical cell membrane properties and signaling. As such, a ceramide imbalance is involved in human pathologies including many forms of cancer, metabolic and neurodegenerative diseases. The molecular control of ceramide levels as a target area for pharmacological intervention has matured significantly in the recent years. Yet, a molecular/structural understanding of the regulation and function of membrane-associated enzymes involved in ceramide synthesis is lacking. To decipher the molecular and structural biology of ceramide homeostasis in health and disease, we develop an integrated research program on intramembrane enzymes involved in the metabolism of ceramides.
Main publications
• Healey RD, et al. (2021) Angew Chem Int Ed Engl. Oct 20. doi: 10.1002/anie.202109967
• Vasiliauskaité-Brooks I, et al. (2018) Nature Commun. Dec 21;9(1):5437.
• Vasiliauskaité-Brooks I, et al. (2017) Nature Apr 06;544:120-123.
Funding
• 2023-2026 ANR 2023-CERAMM-JCJC
• 2021-2023 Muse 2021-CERHOM-Coordonnateur
Collaborations
• Christoph Arenz (Munich)
• Shibom Basu (EMBL Grenoble)
• Thornsten Hornemann (Zurich)
Alumni
• Robert Healey (Post-doc)
• Ana Sofia Ferreira Ramos (Post-doc)
• Ieva Vasiliauskaité (Post-doc)
