Team Hugues DUFFAU – Jean-Philippe HUGNOT
Brain plasticity, stem cells and diffuse low-grade gliomas
Project Epidemiology of gliomas and physiological study of the spinal cord
PRINCIPAL INVESTIGATOR
IGF staff involved
Valérie RIGAU
PU-PH UM
Amélie DARLIX
Collaborateur CHU
Descriptive, analytical and clinical epidemiology of primary central nervous system tumors
As part of the French Brain Tumor DataBase (coordinated by the person in charge – LB), we collect all incident cases with histological confirmation of all primary CNS tumors in France. We are studying the incidence of each histological type and subtype, and their geographical distribution. Several clinical epidemiology studies have already been carried out (glioma, ganglioglioma, solitary fibrous tumors, central neurocytomas). In addition to continuing this work, we are now planning etiological research studies, in particular with the national clinico-biological database of glioblastomas (BCB-GB) approved by INCa (French Institute National du Cancer) which is also coordinated by the person in charge (LB).
Glioma MRI Images
Main publications
• Uro-Coste E., et al., (2023) Brain Pathol. Nov 23:e13223.
• Bauchet L., et al., (2023) Neuro Oncol. 25, 1366.
• Amelot A., et al., (2023) Neurology 100(14):e1497.
• Bikfalvi A., et al., (2023) Trends Cancer. Jan;9(1):9.
• NG S. et al., (2020) Neuro Oncol. 22:851.
Funding
• INCa
• Des Etoiles dans la Mer
• ARTC Sud, ARTC Nord, ARTC Pau, Lions Club
• ARS Occitanie
• Ligue Nationale Contre le Cancer
Collaborations
● All neurosurgery departments and pathology laboratories involved in the management of primary CNS tumors in France
● University hospital center of Angers for the BCB-GB
● International collaborations: Brain Tumor Epidemiology Consortium (LB past Co-President), Central Brain Tumor Registry of the United States, etc.
Alumni
● Mohamed Khettab (Thesis in progress)
● Amélie Darlix (Thesis 2016)
● Sonia Zouaoui (Thesis 2015)
Physiological and biological study of human spinal cord harvested from brain-dead patients and organ donors
As part of the Biomedicine Agency’s work on organ donation in humans, we take scientific samples from the spinal cord, dorsal root ganglia and nerve roots. In particular, we are studying the stem cells present in the human spinal cord (Pr. JP Hugnot), the mechanisms involved in pain (IGF, E. Bourinet team), human microglial cells (IGF, H. Hirbec, F. Rassendren team), the morphological characteristics of human myelin and the structure of the spinal cord using high-field MRI (F. Perrin Inserm/Univ Montpellier), somatosensation (C. Rivat/J. Valmier), etc. We are working with teams across the Atlantic to produce atlases of the human spinal cord and spinal ganglia.
Human spinal cord
Main publications
• Yadav A., et al., (2023) Neuron 111(3):328-344.e7.
• Ripoll C., et al., (2023) Cell Mol Life Sci. 80(7):181.
• Defaye M., et al., (2022) J Clin Invest. 132(12):e154317.
• Bauchet L., et al., (2022) Methods Mol Biol. 2389:103-110.
Collaborations
● Agence de la Biomédecine and transplantation unit CHU de Montpellier, Montpellier, France
● University of Montpellier, INSERM U1198, Institut Universitaire de France
● Inserm U-1298, INM, Montpellier, France
● FHU INOVPAIN (Nice, France)
● INSERM UMR1291, CNRS UMR5051, University of Toulouse III, Toulouse, France.
● International collaborations: Columbia University, New York, NY, USA; National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA; Ottawa Hospital Research Institute, Ottawa, ON, Canada; Ottawa Hospital Research Institute, Ottawa, ON, Canada; Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
● IGF: E Bourinet, PF Mery, H Hirbec
