Team Hugues DUFFAU – Jean-Philippe HUGNOT
Brain plasticity, stem cells and diffuse low-grade gliomas
Project Connectome of the human brain: mapping, plasticity and meta-networks
PRINCIPAL INVESTIGATOR
We are exploring the connectome of the human brain, in particular the neural bases underlying movement, language, cognitive and emotional functions, and non-verbal communication, as well as their capacity for reorganisation in gliomas. We are developing meta-network models of brain information processing, based on dynamic interactions between neural networks. We use multimodal approaches, particularly those used in awake surgery: behaviour, neurophysiology and neuroimaging, and their modulation before and after glioma resection. This enables us to establish an original link between neuro-oncology and cognitive neuroscience.
Global and dynamic onco-functional framework in low-grade gliomas, illustrating the interactions between the course of the tumor, reactional neuroplastic mechanisms of the connectome, and tailored therapeutic strategies.
Main publications
• Ng S, et al (2023) Brain 146:3088-3100.
• Herbet G et al (2022) Nat Commun 13:328.
• Herbet G, et al (2020) Physiol Rev 100(3):1181–1228.
• Herbet G,et al (2019) Brain 142(8):2207–2214.
Collaborations
• Fudan University, Shanghai, Chine
• UCL, London, UK
• Iowa University, Iowa-City, USA
• Trento University, Italie
Alumni
● Guillaume Herbet MCU, University of Montpellier
