Team Stéphane DALLE – Eric RENARD
Innovative therapeutics for diabetes
Project Mechanisms of beta-cell alteration: involvement of amyloidogenic proteins and pesticides
PRINCIPAL INVESTIGATOR
IGF staff involved
Magalie RAVIER
CRCN INSERM
Ambrine ARRAR
IE INSERM
This research group is interested in identifying the mechanisms by which beta-cells are altered in response to proteotoxic and/or environmental stresses. To this end, insulin-secretory function, survival and the integrity of protein degradation pathways (autophagy, ubiquitin-proteasome system) are assessed in beta-cell lines and pancreatic islets (murine and human) using a combination of cell/molecular biology and imaging techniques.
More specifically, the current project aims to assess the impact of chronic exposure to a mixture of low doses of pesticides on the onset of type 2 diabetes and Parkinson’s disease, and to identify possible common mechanisms of alteration between these two pathologies. Developed in collaboration with INRAE and ANSES, this project is conducive to the identification of new strategies – both therapeutic and preventive – aimed at protecting beta-cells.
Potential mechanistic links between Parkinson’s disease and type 2 diabetes
Main publications
• Brown MR., et al. (2022) Cell Death Dis, 13(4), 353.
• Costes S., et al. (2021) Int J Mol Sci, 22(10), 5303.
• Costes S. (2018) Curr Opin Pharmacol, 43,104-110.
• Ruiz L., et al. (2018) Cell Death Dis, 9(6), 600.
Funding
• 2023 Gilberte et Jacques Tacussel Award from the National Academy of Medicine- Laureate
• 2022-2025 ANSES – DEEP project – Coordinator
• 2022-2024 French Society of Diabetes – Coordinator
Collaborations
• Thierry Baron (Lyon)
• Aleksey Matveyenko (Rochester, USA)
• Laurence Payrastre (Toulouse)
• Human Cell Design
Alumni
• Nour Mesto (post-doc)
