Team Stéphane DALLE – Eric RENARD
Innovative therapeutics for diabetes
Project Incretin hormones and signaling
PRINCIPAL INVESTIGATOR
IGF staff involved
Safia COSTES
CRCN INSERM
Gyslaine BERTRAND
CRHC CNRS
This research group focuses on G protein-coupled receptors (GPCRs) of the glucagon family, and in particular on receptors for the incretin hormones glucagon-like peptide-1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR). These two types of receptors are major therapeutic targets for type 2 diabetes and obesity. We are particularly interested in how islet cells perceive environmental stimuli to regulate pancreatic hormone secretion in response to incretins.
Spatiotemporal signaling is studied in pancreatic islets (murine and human) under normal and diabetic conditions, combining biochemical, molecular biology and fluorescent probe techniques with live cell imaging methods.
More specifically, current projects include:
- GLP-1R and GIPR signaling and the interest of combined GLP-1/GIP incretin therapy for pancreatic islets
- Control of calcium exchange between the endoplasmic reticulum and mitochondria
Clusters of pancreatic islet cells. A. GLP-1R immunofluorescence (green). B. Immunofluorescence of phosphorylated CREB (orange). C. Localization of PKC at the plasma membrane recorded by total internal reflection fluorescence (TIRF) microscopy. D. Actin filaments (green) and FAK activation (red) at actin filament tips.
Main publications
• Zaïmia M., et al (2023) Cell Rep, 42, 113326
• Costes S., et al. (2021) Int J Mol Sci, 22, 5303
• Leduc M., et al. (2017) Diabetologia, 60, 10
• Ravier MA., et al. (2014) Diabetologia, 57, 3
• Gilon P., et al. (2014) Cell Calcium, 56, 5
Funding
• 2022-2025 : ANR 2021-TriMAMvirate – Partner
• 2020-2023 : Société Francophone du Diabète (SFD2020) – Coordinator
• 2018-2019 : Région Occitanie (Contrat de Recherche Prématuration)
Collaborations
• Patrick Gilon (Bruxelles)
• Jennifer Rieusset (Lyon)
• Philippe Rondard (Montpellier)
• Annie Varrault (Montpellier)
• Eli Lilly
Alumni
• Nour Zaïmia (PhD student)
• Joëlle Obeid (PhD student)
• Michèle Leduc (post-doc)
