Team Stéphane DALLE – Eric RENARD

Innovative therapeutics for diabetes

Project Automated insulin delivery by wearable or implantable systems

PRINCIPAL INVESTIGATOR

Éric Renard
PU-PH1, UM

IGF staff involved
Orianne VILLARD
CC-AH University of Montpellier
Anne FARRET
PH, Montpellier University Hospital
Jérôme PLACE
IGE, University of Montpellier

This project aims at providing an insulin supply closer to physiology for the treatment of type 1 diabetes through automated insulin delivery using control algorithms which modulates insulin infusion from wearable or implantable pumps based upon continuous glucose monitoring by electro-enzymatic sensors inserted in the interstitial milieu. The research team evaluates the safety and efficacy of closed-loop systems on glucose control and improvement of users’ quality of life.

The safety and efficacy of automated insulin delivery systems on blood glucose control in type 1 diabetes is assessed by clinical trials in various populations living with type 1 diabetes: children and adolescents with recent  diagnosis, people with high risk of hypoglycemia, people with high blood glucose variability.

Current projects include :

  •  Assessment of the efficacy of automated insulin therapy (‘artificial pancreas’) early initiated after diagnosis on blood glucose control in children and adolescents with type 1 diabetes : randomized comparison with a conventional insulin therapy for 1 year, followed by an optional extension for 1 year (AP-AT-DIAGNOSIS).
  • Improving Type 1 Diabetes Treatment Through Unobtrusive Continuous Diabetes Management Technology (MuSiC4Diabetes).
  • A bionic invisible pancreas to forget diabetes (FORGETDIABETES).

Automated insulin delivery systems : A. OmniPod 5 assessed in the project AP-AT-DIAGNOSIS ; B. System developed in the project MuSiC1Diabetes.

Main publications

• Reznik Y., et al. (2024) Diabetes Obes Metab, 26, 622
• Renard E., et al (2023) Diabetes Care, 46, 2180
• Coutant R., et al. (2023) Diabetes Technol Ther, 25, 395
• Renard E., et al. (2022) Diabetes Obes Metab, 24, 511
• He J., et al. (2022) J Control Release, 341, 487

Funding

• 2023-2027 : MuSiC4Diabetes – HORIZON-EIC-2022-PATHFINDERCHALLENGES-01 – Partenaire
• 2022- 2027 : AP-AT-DIAGNOSIS –PHRC 2021 – Coordinateur
• 2020-2025 : FORGETDIABETES – HORIZON 2020-EIC-FETPROACT-2019 – Partenaire

Collaborations

• Claudio Cobelli (Padoue)
• Marc Breton (Charlottesville)
• Boris Kovatchev (Charlottesville)
• Martin Richter (Munich)