Team Sylvaine ARTERO – Philippe COURTET
Environnement, biomarkers, neuropsychiatry
Project Diet, inflammation, microbiota and cognitive decline
PRINCIPAL INVESTIGATOR
IGF staff involved
Sylvie CLAEYSEN
CRHC INSERM
Sébastien GUILLAUME
PU-PH Université Montpellier
In our ageing societies, identifying new ways to preserve cognitive health has become a major concern.
We now know that diet can influence key mechanisms involved in Alzheimer’s disease (AD), such as insulin resistance, inflammation and changes in the microbiota.
We are interested in analyzing the interrelationships between excessive sugars consumption, inflammatory pathologies, alterations in the microbiota (both intestinal and oral) and the onset of AD.
Our current projects:
- Analyze in cohorts, interaction between sugars consumption, periodontitis (inflammatory and dysbiotic pathology) and cognitive decline.
- Evaluate in clinical populations the links between sugars consumption, inflammation, microbial signatures, metabolomic profiles and cognitive profiles
- Validate in an animal model the impact of sugars on inflammation, neuroinflammation, microbiota and cognition
Main publications
• Gentreau M., et al. (2023) Am J Geriatr Psychiatry, 31,932
• Gentreau M., et al. (2022) J Alzeimers Dis, 89,1293
• Gentreau M., et al. (2022) Nutrients 14,2485
• Gentreau M., et al. (2020) Nutrients 12, 3619
• Gentreau M., et al (2020) Alzheimers Dement 16,1043
Funding
• 2022-2025 ANR DentalCog (PI)
• 2021 Coen (PI)
• 2019-2014 Région Occitanie-Partner
• 2019-2022 France Alzheimer (PI)
Collaborations
• Michel Raymond and Claire Berticat (Montpellier)
• Jerome Maller (Australia)
Alumni
• Mélissa Gentreau (Thesis, 2019-21)
• Fabienne Cyprien (Thesis, 2014-16)
