Plateforme de Vectorologie de Montpellier (PVM)

Lentivectors and AAV Core Facility

Arnaud Monteil
CRHC, CNRS
Céline Lemmers
IR2, Inserm

The Plateforme de Vectorologie de Montpellier (PVM) is affiliated to BioCampus Montpellier and is dedicated to the production of recombinant viral particles for any requesting laboratory. Viral vectors enable the efficient, reproducible and targeted expression of genes in different cell types. The IGF Core Facility of the Montpellier Vectorology Platform specializes in the production of recombinant Lentiviruses, Retroviruses and AAVs.

Our team is here to help you with your projects involving the use of viral vectors for gene transfer and genome editing. They can be used, for example, for:

• marking cell cohorts, studying lineages or neuronal networks
• studying cell activity (neurons, cardiac cells, β-pancreatic cells, etc.)
• gain/loss-of-function approaches to understand gene functions
• immortalization, transformation and tumor induction
• vaccines
• gene therapy…

The properties of these viral particles differ according to the nature of the virus from which they are derived. The choice of particle type will depend on the research project issues.

Services
The technical platform at IGF specializes in the production of Lentiviruses derived from HIV-1, murine Retroviruses and AAVs (Adeno-Associated Viruses) of various serotypes.
Do you have a question, a quotation or a production order? Do not hesitate to contact us or visit the PVM platform website.

Researchers
Arnaud
Monteil
CRHC, CNRS
  IGF Sud 129
  04 34 35 92 50
Know more >

Technicians and engineers
Céline
Lemmers
IR2, Inserm
  IGF Sud 121
  04 34 35 92 45
Know more >

IGF Publications
  • Kumar P, Courtes M, Lemmers C, Le Digarcher A, Coku I, Monteil A, Hong C, Varrault A, Liu R, Wang L, Bouschet T. Functional mapping of microRNA promoters with dCas9 fused to transcriptional regulators. Genet., doi :10.3389/fgene.2023.1147222
  • Impheng H, Lemmers C, Bouasse M, Legros C, Pakaprot N, Guérineau NC, Lory P, Monteil A. The sodium leak channel NALCN regulates cell excitability of pituitary endocrine cells. FASEB J. 2021 May;35(5):e21400. doi: 10.1096/fj.202000841RR. PMID: 33793981.
  • Candelas M, Reynders A, Arango-Lievano M, Neumayer C, Fruquière A, Demes E, Hamid J, Lemmers C, Bernat C, monteil A, Compan V, Laffray S, Inquimbert P, Le Feuvre Y, Zamponi GW, Moqrich A, Bourinet E, Méry PF.2 T-type calcium channels shape electrical firing in mouse Lamina II neurons. Sci Rep 9, 3112 (2019). doi.org/10.1038/s41598-019-39703-3
  • Monteil A, Chausson P, Boutourlinsky K, Mezghrani A, Huc-Brandt S, Blesneac I, Bidaud I, Lemmers C, Leresche N, Lambert RC, Lory P. Inhibition of Cav3.2 T-type Calcium Channels by Its Intracellular I-II Loop. J Biol Chem. 2015 Jun 26;290(26):16168-76. doi: 10.1074/jbc.M114.634261. Epub 2015 Apr 30. PMID: 25931121; PMCID: PMC4481217.
Publications external to IGF
  • Guo Y, Gabola M, Lattanzio R, Paul C, Pinet V, Tang R, Turali H, Bremond J, Longobardi C, Maurizy C, Da Costa Q, Finetti P, Boissière-Michot F, Rivière B, Lemmers C, Garnier S, Bertucci F, Zlobec I, Chebli K, Tazi J, Azar R, Blanchard JM, Sicinski P, Mamessier E, Lemmers B, Hahne M. Cyclin A2 maintains colon homeostasis and is a prognostic factor in colorectal cancer. J Clin Invest. 2021 Feb 15;131(4):e131517. doi: 10.1172/JCI131517. PMID: 33332285; PMCID: PMC7880422.
  • Wichit S, Hamel R, Yainoy S, Gumpangseth N, Panich S, Phuadraksa T, Saetear P, Monteil A, Morales Vargas R, Missé D. Interferon-inducible protein (IFI) 16 regulates Chikungunya and Zika virus infection in human skin fibroblasts. EXCLI J. 2019 Jun 27;18:467-476. doi: 10.17179/excli2019-1271. PMID: 31423125; PMCID: PMC6694701.